Effect of S-adenosylmethionine on total parenteral nutrition-associated cholestasis
نویسندگان
چکیده
Methods: Twenty-four newborn rabbits were randomly divided into 3 groups: normal control group receiving breast milk, TPN group receiving TPN at a dose of 200 kcal/kg per day, and SAMe group receiving TPN plus SAMe at an intravenous dose of 100 mg/kg per day. Blood and liver samples were collected one week later. The levels of serum bile acid, alanine aminotransferase (ALT), alkaline phosphatase (AKP), total bilirubin, direct reaction bilirubin, albumin and globulin levels were detected by an automatic biochemical analyzer. Hepatic pathological changes were observed under the light microscope, and apoptosis of hepatocytes was determined with the TUNEL method.
منابع مشابه
The Effect of Fish Oil-Based Lipid Emulsion and Soybean Oil-Based Lipid Emulsion on Cholestasis Associated with Long-Term Parenteral Nutrition in Premature Infants
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